{"id":55733,"date":"2014-10-10T11:11:22","date_gmt":"2014-10-10T15:11:22","guid":{"rendered":"http:\/\/valorguardians.com\/blog\/?p=55733"},"modified":"2014-10-10T12:44:29","modified_gmt":"2014-10-10T16:44:29","slug":"previews-of-coming-attractions","status":"publish","type":"post","link":"https:\/\/www.azuse.cloud\/?p=55733","title":{"rendered":"&#8220;Previews of Coming Attractions\u201d"},"content":{"rendered":"<p>People wonder just how bad the Ebola outbreak could get. Well, with a bit of understanding of the relevant mechanisms, knowledge of the math involved, and a spreadsheet, putting together a \u201cquick and dirty\u201d approximate model for the spread of that disease is relatively easy.<\/p>\n<p>What it shows may be somewhat hard to swallow. And it is a simplified model; reality will be somewhat more complex. But for the early stages of an epidemic \u2013 and we\u2019re still in the relatively early stages of this one \u2013 I think this should be relatively close.<\/p>\n<p><span style=\"text-decoration: underline;\">First, a few known facts and\/or best estimates for the current outbreak and about Ebola itself<\/span>.<\/p>\n<ol>\n<li>Although the first case was reported 6 months ago, the current outbreak has actually been ongoing since Dec 2013. The index case infection(s) <a href=\"http:\/\/www.who.int\/csr\/disease\/ebola\/EVD_WestAfrica_WHO_RiskAssessment_20140624.pdf\">occurred in Guinea, in late Dec 2013<\/a>. It simply wasn\u2019t recognized as Ebola for around 3 months.<\/li>\n<li>The mortality rate (percentage of those infected with the disease who die) for a disease outbreak cannot be calculated until after the outbreak has run its course. However, an estimate &#8211; the current case fatality rate (CFR) \u2013 can be calculated. The CFR is a snapshot in time, and tends to rise during the course of an outbreak as more complete information becomes available and some of the patients sick at the time of last calculation die. For the current outbreak, <a href=\"http:\/\/healthmap.org\/site\/diseasedaily\/article\/estimating-fatality-2014-west-african-ebola-outbreak-91014\">data indicates that the CFR for the current outbreak is approximately 53%<\/a>.<\/li>\n<li>The total number of reported Ebola cases during the current outbreak is believed to be <a href=\"http:\/\/www.vox.com\/2014\/10\/6\/6889037\/reporting-ebola-epidemic-virus-outbreak\">only approximately 40% of the actual number of cases<\/a>.\u00a0\u00a0 Roughly 60% of the cases (and deaths)in the current outbreak are believed to have never been reported \u2013 or in other words, multiply the current reported totals for cases and deaths by 2.5 to get the best guess at the true number.<\/li>\n<li>Facts and best estimates concerning Ebola virus disease.<\/li>\n<\/ol>\n<ul>\n<li>The average Ebola incubation period seems to be about 10 days (min observed is 2 days; max observed is 21).<\/li>\n<li>During incubation, patients are asymptomatic (without symptoms). Individuals are not in general contagious prior to becoming symptomatic.<\/li>\n<li>At the onset of symptoms, patients begin shedding the virus in bodily fluids and become contagious.<\/li>\n<li>Transmission of Ebola appears to be via human-to-human transmission through close contact and\/or contact with contaminated fomites\/surfaces. Contact with an symptomatic Ebola sufferer\u2019s bodily fluids (sweat, urine, feces, vomit, semen, vaginal secretions, mucous, saliva, or blood) is believed to be the mechanism by which Ebola is transmitted from person to person. For that reason, shaking hands with or standing within 1 meter of an Ebola patient without PPE is considered close contact.<\/li>\n<li>The virus appears to enter the human body through mucous membranes or open wounds.<\/li>\n<li>Aerial transmission of Ebola does not appear to be a normal means of transmission from human-to-human. However, the possibility cannot be ruled out. Ebola Reston is believed to have spread between primates in different rooms of the famous Hazelton \u201cmonkey house\u201d in Reston, VA, through the facility\u2019s ventilation system. After analysis, aerial transmission through the facility\u2019s ventilation system was determined to have been the most likely mechanism by which that Ebola variant spread.<\/li>\n<\/ul>\n<p><span style=\"text-decoration: underline;\">How epidemics work.<\/span><\/p>\n<p>An epidemic in an immunologically na\u00efve population (e.g., one that has no previous exposure, and thus no natural resistance to the disease) works and can be modeled at a somewhat simplistic level as follows.<\/p>\n<ol>\n<li>A first case \u2013 termed the index case \u2013 becomes infected. This begins the first generation of the outbreak.<\/li>\n<li>The index case proceeds through the disease\u2019s incubation period. For Ebola, this is on average 10 days. For Ebola, the individual is not contagious during the incubation period.<\/li>\n<li>The individual becomes contagious. For Ebola, this occurs with the onset of symptoms. Also for Ebola, the period during which a sufferer is contagious lasts until they either recover (average is approximately 16 days) or die (usually around day 10 after onset of symptoms). (One caveat here: the Ebola virus persists in certain organs of recovered Ebola patients for up to 90 days after clinical recovery. Though the recovered patient\u2019s body does eventually rid itself of the virus, transmission to others after recovery can occur. In particular, sexual transmission of Ebola by a \u201crecovered\u201d Ebola patient several weeks after clinical recovery has been recorded.)<\/li>\n<li>Transmission to others occurs during the period while an infected person is contagious. During this period, the individual transmits the disease to some number of other individuals. The average number of persons to whom each sufferer transmits the disease is a critically important parameter, called the \u201creproduction number\u201d. So long as this number is greater than 1, the number of people infected will continue to increase. It\u2019s just a question of how fast.\u00a0 For the current Ebola outbreak, the reproduction number is estimated to be <a href=\"http:\/\/www.washingtonpost.com\/national\/health-science\/the-ominous-math-of-the-ebola-epidemic\/2014\/10\/09\/3cad9e76-4fb2-11e4-8c24-487e92bc997b_story.html\">somewhere between 1.5 and 2<\/a>.<\/li>\n<li>The transmission to others referenced in step 4 begins the next generation of the virus. Steps 1 through 4 then repeat.<\/li>\n<\/ol>\n<p>That\u2019s it. Until the numbers of persons with some type of immunity to the disease (either through survival or vaccination) in the affected population becomes significant, the above is a reasonably accurate \u2013 though somewhat crude \u2013 description of how an infectious disease propagates through a susceptible population.\u00a0 It will hold until something (deaths, developed immunity, behavioral changes, whatever) changes the transmission cycle of the disease &#8211; usually by changing the reproduction number.<\/p>\n<p>Those familiar with calculus might be wondering if this is a process exhibiting exponential growth. The answer, unfortunately, is yes. Epidemics in fully susceptible populations are indeed exponential growth scenarios until \u201cherd immunity\u201d (the fraction of the population immune due to prior exposure or vaccination) becomes significant \u2013 or until the population dies out, or something else intervenes to reduce the reproduction number below 1.<\/p>\n<p><span style=\"text-decoration: underline;\">The Model<\/span>.<\/p>\n<p><a href=\"https:\/\/www.azuse.cloud\/wp-content\/uploads\/2014\/10\/Epidemic_Spreadsheet.xls\">Here is a simplified spreadsheet model<\/a> I\u2019ve come up with for the current West Africa Ebola outbreak. As noted, it\u2019s a rather crude, &#8220;quick and dirty&#8221; model. But it gives a reasonable idea of what may be in store; I don&#8217;t think it&#8217;s grossly in error.\u00a0 Format is Excel 97-2003.\u00a0 If anyone with more knowledge of the subject or the parameters in question has criticism or comment, I&#8217;m all ears. Getting it right is what&#8217;s important.<\/p>\n<p>Fair warning:\u00a0 I would suggest you (a) sit down, and (b) get a cup of coffee (or something stronger) before you look at the model.\u00a0 And I wouldn&#8217;t recommend do so immediately after or while eating.<\/p>\n<p>Assumptions used were the following.<\/p>\n<ul>\n<li>Single index case in late Dec 2013.<\/li>\n<li>53% mortality rate.<\/li>\n<li>Reproduction number of 1.57<\/li>\n<li>Average incubation period of 10 days.<\/li>\n<li>Transmission on average occurs (and thus begins the next generation of the epidemic) on day 5 after each infected individual\u2019s symptoms begin.<\/li>\n<li>Reported cases and deaths are each 40% of actual.<\/li>\n<li>Estimates based on averages are reasonably representative of physical reality and will not be grossly in error.<\/li>\n<\/ul>\n<p>For 9 October &#8211; the start date of the model&#8217;s generation 20 of the outbreak &#8211; this model predicted a reported number of cases of 7,724 and a reported number of deaths of 4,090.<\/p>\n<p>Per the CDC website, on 8 October 2014, the reported number of cases was <a href=\"http:\/\/www.cdc.gov\/vhf\/ebola\/outbreaks\/2014-west-africa\/case-counts.html\">8,011; the reported number of deaths was 3,857<\/a>.<\/p>\n<p>On the &#8220;bright side&#8221; &#8211; if you can call it that &#8211; the model I developed doesn\u2019t predict 1.4 million cases until late Feb\/early Mar 2015. <a href=\"http:\/\/www.washingtonpost.com\/national\/health-science\/cdc-ebola-could-infect-14-million-in-west-africa-by-end-of-january-if-trends-continue\/2014\/09\/23\/fc260920-4317-11e4-9a15-137aa0153527_story.html\">Without changes in the outbreak, CDC predicts that number of cases by late January<\/a>.<\/p>\n<p>I guess I could say \u201cHappy Halloween\u201d at this point; the above is certainly scary enough. But I don\u2019t see much to be happy about above.<\/p>\n<p><em><span style=\"text-decoration: underline;\"><strong>THIS is why we need to do everything possible to keep this sh!t out of the United States. Period.<\/strong><\/span><\/em><\/p>\n<p>Are you listening, Mr. President?<\/p>\n","protected":false},"excerpt":{"rendered":"<p>People wonder just how bad the Ebola outbreak could get. Well, with a bit of understanding &hellip; <a title=\"&#8220;Previews of Coming Attractions\u201d\" class=\"hm-read-more\" href=\"https:\/\/www.azuse.cloud\/?p=55733\"><span class=\"screen-reader-text\">&#8220;Previews of Coming Attractions\u201d<\/span>Read more<\/a><\/p>\n","protected":false},"author":623,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[220,46,9,84,188],"tags":[],"class_list":["post-55733","post","type-post","status-publish","format-standard","hentry","category-the-floggings-will-continue-until-morale-improves","category-barack-obama","category-foreign-policy","category-military-issues","category-reality-check"],"_links":{"self":[{"href":"https:\/\/www.azuse.cloud\/index.php?rest_route=\/wp\/v2\/posts\/55733","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.azuse.cloud\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.azuse.cloud\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.azuse.cloud\/index.php?rest_route=\/wp\/v2\/users\/623"}],"replies":[{"embeddable":true,"href":"https:\/\/www.azuse.cloud\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=55733"}],"version-history":[{"count":0,"href":"https:\/\/www.azuse.cloud\/index.php?rest_route=\/wp\/v2\/posts\/55733\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.azuse.cloud\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=55733"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.azuse.cloud\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=55733"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.azuse.cloud\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=55733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}